The natural cures for cancer niche sounds like a good one since you can write from the heart. (Unfortunately, so sorry!) It is pretty competitive but if you can, try to research hot new trends, new meds, new treatments highlight those keywords in your titles.
I guess your new mini site on WP is the handbag site? One quick tip.
You need keywords in your title, not domainname.com.
So go to your WP admin>>options>>general and for name of blog put the descriptive name with some good keywords. For instance my 5 Star blog isnt just "5 Star Affiliate Blog" my title is "5 Star Affiliate Marketing Blogs, Google and SEO Blog." So I also get traffic when people look for Google blogs and SEO blogs.
So for yours you could use Genuine Designer Celebrity Handbags for Rent.
Just a quick idea, you need to do KW research to see if those are best.
Then use the same keyword phrase in the top large font and a couple other places on the page.
Then each new blog you write do the same thing. Designer Gucci Handbags for Rent or whatever in title, H1 font on page and regular font on page. Do KW research to see if Gucci Handbags or Gucci Purses or some other phrase gets the most searches. Remember too, the more specific the phrase the easier it COULD be (not always) to rank higher and get seen.
Go to Seobook
SEO Book Keyword Suggestion Tool
Type handbags and you'll see some of the most popular search terms to write articles about.
I'm not into designer handbags AT all and could care less. But here's an idea of how to weave in good keywords.
Replica handbags gets a ton of searches. So write an article about "Why Buy a Replica Handbag when you can Rent the Real Thing? Write a couple paragraphs using those KW then shows pic of and link to products that would fit that type of buyer.
Just throwing out some ideas...