I think that merchants should definitely use different networks for multiple reasons
1. Get access to large number of affiliates
2. Allows the merchant to negotiate affiliate payout
3. Builds credibility in the market when your site is listed in different locations
4. Build brand value
5. Get access to larger traffic.
6. BACKUP
From affiliate point of view its good because affiliates can select the highest payout for a particular offer in different networks.
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